During our long history, Creative Biolabs develops and commercializes a full range of integrated platforms and innovative services based on aptamer screening. We have extensive experience in the field of aptamer screening for organic small molecule targets. We also provide in-house access to qualified aptamers and the Capture SELEX technology platform to assist our customers in their research and project development.
Organic small molecules are challenging targets for screening aptamers, and they are often not suitable for immobilization on solid surfaces as in traditional SELEX programs. Capture-SELEX program can select DNA aptamers using solutes as targets by constructing a special SELEX library that immobilizes oligonucleotide libraries on magnetic beads or other surfaces for screening purposes.
Fig 1. Capture-SELEX strategy [1].
Capture-SELEX is a variant of traditional SELEX that is similar to the FluMag-SELEX.
The Capture-SELEX process is very flexible in its configuration. The elution step can be easily combined with a negative or anti-selection step to influence the specificity of the aptamer to be selected. In addition to single target substances, the capture-SELEX process is also suitable for target mixtures containing two or more different substances for parallel selection of aptamers of different targets. In addition, the capture-SELEX principle is equally attractive for other classes of target molecules, such as polysaccharides, peptides or proteins.
Creative Biolabs is a leading global aptamer development company. After more than a decade of exploration and expansion, we have demonstrated solid expertise and capabilities in biotechnology and have expanded our research and service capabilities to include all areas of aptamer development.
Our commitment to this long-term goal has driven us to provide the highest quality services to our customers in order to further advance the biotechnology/pharmaceutical industry. If you are interested in this service, please contact us for more details.
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