With years of experience in antibody drug discovery, Creative Biolabs is confident to provide a full range of aptamer development services to advance the use of aptamers in disease therapy and life science applications, and to provide aptamer screening services for different forms of targets with our well-structured SELEX technology platform. We also provide post-screening services for aptamers with our excellent team of experts and extensive experience.
Aptamers are broadly defined as single-stranded oligonucleotides or peptides with antibody functions that can form specific steric structures to recognize specific proteins. Single-stranded DNA or RNA can form a variety of thermodynamically stable three-dimensional spatial structures with certain substances to become various functional molecules.
| Diversity of Targets | Aptamers can be screened against a variety of molecular targets, including toxins that are difficult to produce antibodies to or targets with low immunogenicity. |
| High Screening Efficiency | Current automated DNA/RNA synthesis technologies also allow for easy, cost-effective, large-scale fabrication and automated chemical modification of aptamers. |
| Stable Properties | The relatively simple chemical structure of aptamers requires complete conformational recovery even after thermal or chemical denaturation, while aptamers typically have a long shelf life. |
| Wide Rrange of Applications | Aptamers have been used in many other biomedical scenarios, including in vitro bioanalysis and in vitro diagnostics (IVD), bioimaging, biomarker discovery, and aptamer-assisted drug discovery. |
Aptamers are defined as "artificial antibodies" with high affinity and specificity to the intended target and have been widely used in basic life science research, clinical diagnostics and drug development, etc. Creative Biolabs has organized a group of outstanding experts who have accumulated extensive experience in aptamer development. We provide the best one-stop in vitro aptamer selection service through our extensive SELEX technology platform.
The application of aptamers is limited due to their hydrophilicity, high affinity loss during production and in vivo degradation. Therefore, Creative Biolabs provides various optimization methods to improve the performance of aptamers. They mainly include, but are not limited to: aptamer basic sequence optimization, aptamer structure stability optimization, etc.
To ensure the efficiency of aptamers in various applications, these selected aptamers must be highly stable, of moderate length and with good pharmacokinetic properties. Therefore, sufficient assays are required to characterize and assess the properties of the aptamer of interest. Our technology platform provides services including aptamer structure determination, binding kinetic measurements and specificity testing.
Aptamers composed of natural nucleotide monomers are often rapidly degraded in vivo and exhibit poor pharmacodynamic properties. Therefore, in vitro analysis is an important component in assessing the success of aptamer development, both for natural aptamers obtained through SELEX screening and for chemically modified aptamers. Creative Biolabs provides services such as aptamer stability analysis and cytotoxicity assays.
For more information and details of our services, please contact us.
Creative Biolabs provides the most comprehensive services for aptamer development projects. Our cutting-edge technology allows our researchers to fulfill your requirement from various aspects and to offer the most suitable solution for your project.
