Aptamer Screening Services for Unpurified Protein

Creative Biolabs has an experienced team of technical staff to provide aptamer screening services for different targets ranging from purified proteins to whole cells and tissues. We are committed to providing our customers with high-quality and high affinity aptamers.

Although nucleic acid aptamers targeting purified proteins have a wide range of applications, the screening process is complicated and generally requires more than ten rounds of screening, which consumes a lot of manpower, financial and time resources, and the resulting nucleic acid aptamers may also have low affinity and poor specificity, which affect their subsequent applications.

Due to the structural and chemical properties of aptamers, there are theoretically a wide variety of targets, and aptamer screening techniques have been developed for non-purified proteins as targets, among which the more representative ones are cell SELEX and in vivo SELEX.

Cell SELEX

Advantages	Disadvantages
The ability to screen for appropriate aptamers for a wide range of targets. Requiring prior knowledge of the molecular conformation of the target. Avoid the destruction of target structures during purification. The potential to screen for aptamers of unknown molecules.	Difficulty in directly screening for aptamers of less expressed proteins. Interference of non-specific binding. Complex target composition and the need for multiple rounds of screening to obtain high-affinity aptamers.

Recent advances in SELEX technology have expanded from aptamer selection for purified proteins to selection for living cells, and cell-SELEX represents an integrated technology that promises to revolutionize the way we diagnose.

In Vivo SELEX

Advantages	Disadvantages
Potential for targeted drug delivery and effective design of diagnostic reagents. High affinity of screened aptamers. Real-time screening.	Significant individual differences in the screened aptamers. Degradation properties of oligonucleotide molecules in vivo. Low efficiency and high cost.

In vivo SELEX strategies for identifying aptamers that bind tumors in situ have the potential for targeted drug delivery and efficient design of diagnostic reagents.

Workflow of SELEX

Our Services

With our technology platform, Creative Biolabs provides high-quality aptamer screening services for unpurified protein.

SELEX Screening Services for Living Cells and Tissues
Aptamer Screening Services for Targeting Cells

Cell Surface Molecules
Cellular Transmembrane Proteins
Intracellular Targets

We committed to help our customers obtain high-quality aptamers more efficiently. If you are interested in this service, please contact us for more details.

Advantages of Our Services

Creative Biolabs is a leading global aptamer development company. After more than a decade of exploration and expansion, we have demonstrated solid expertise and capabilities in biotechnology and have expanded our research and service capabilities to include all areas of aptamer development.

Extensive experience and advanced biotechnology
Fully customizable experimental design
Competitive prices and the best quality
Best after-sales service

Our commitment to this long-term goal has driven us to provide the highest quality services to our customers in order to further advance the biotechnology/pharmaceutical industry.

Service Process

For research use only. Not intended for any clinical use.