• • Aptamer Screening Services
    • Aptamer Screening Services for Protein
      • Aptamer Screening Services for Unpurified Protein
        • Cell-SELEX Services
        • In Vivo SELEX Services
    • Aptamer Screening Services for Small Molecules
      • Aptamer Screening Services for Molecules with Different Groups
      • Aptamer Screening Services for Homogeneous Molecules
      • Aptamer Screening Services for Chiral Molecules
    • Aptamer Screening Services for Metal Ion
    • Aptamer Screening Services for Multiple Targets
      • Complex Target SELEX Services
      • Toggle SELEX Services
      • Subtractive SELEX Services
      • Counter SELEX Services
  • Aptamer Optimization Services
  • Aptamer Characterization Services
  • Aptamer Analysis Services
  Inquiry

  • * Name: * Phone: * Email:
  • * Services Interested: Project Description:
  • Submit Submit

With extensive experience in aptamer development, our scientists are confident in providing a full range of counter SELEX services to advance science and technology development. Creative Biolabs is able to provide counter SELEX services in an efficient and high-quality manner.

Cell-SELEX is a systematic aptamer screening process commonly used to screen for target proteins on cell membranes. However, the Cell-SELEX procedure still has some drawbacks, such as the interference of dead cells during the selection process and the lengthy experimental procedure. Counter-SELEX is a new negative selection procedure that can effectively eliminate oligomers from surface molecules, often in combination with cell SELEX.

Fig 1. Process of counter SELEX ^[1].

Advantages of Counter SELEX

• High-throughput nucleotide sequencing after counter SELEX helps to shorten the entire aptamer screening process.
• Counter SELEX improves the efficiency of cell SELEX in excluding non-specific interfering sequences.
• Aptamers for a known or unknown target molecule can be screened from the mixed system.

Applications of Counter SELEX

Screening for Target Molecular Aptamers in Mixed Systems

It can be used to find oligonucleotide ligands that specifically bind to a tumor marker, and the target oligonucleotide ligands can be screened by using tissue cells from healthy individuals to remove sequences that bind to the background.

Microbial Detection

For the study of some unknown pathogenic bacteria or viruses, we use them as targets and screen for their corresponding aptamers through the reverse SELEX process, and then further analyze their gene structures.

Fig 2. Schematic Diagram of Modified Cell-SELEX Phases ^[1].

Advantages of Our Services

Creative Biolabs provides the most comprehensive services for aptamer development projects. Our cutting-edge technology allows our researchers to fulfill your requirement from various aspects and to offer the most suitable solution for your project.

• Excellent researchers in the field of aptamer screening
• Efficient and high-quality service at the most competitive price
• Providing high-quality, high affinity aptamers
• Shortest lead time for the success of your project

Service Process

Reference

1. Bakhtiari H, et al. Novel approach to overcome defects of cell-SELEX in developing aptamers against aspartate β-hydroxylase[J]. ACS omega, 2021, 6(16): 11005-11014.

Complex Target SELEX Services
Toggle SELEX Services
Subtractive SELEX Services